Pinning Down Viral Proteins: A New Prototype for Virus–Host Cell Interaction
نویسندگان
چکیده
Pin 1 is an enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins. Recent studies demonstrate that stability of several viral proteins is regulated by phosphorylation-dependent prolyl-isomerization by a host factor Pin1. Pin1 is now positioned as an important modulator of the molecular crosstalk between virus and host cells and could be a unique target for anti-virus therapy. This new type of post-translational modification by Pin1 might be involved in the regulation of other viral proteins.
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2010